USE OF BIOMARKERS IN MONITORING OF TREATMENT OF ACUTE HEMATOGENOUS OSTEOMYELITIS IN CHILDREN
Abstract
biomarkers, bone metabolism, collagen, acute hematogenous osteomyelitis, telopeptides.
Relevance. Today, acute hematogenous osteomyelitis (AHO) remains a serious problem in childhood. According to the WHO, the annual incidence of AHO among children varies from 2 to 13 cases per 100,000 population, depending on the region, age, and level of medical care. Bone collagen biomarkers represent a new and promising tool in the diagnosis and monitoring of bone pathologies in children.
The aim of the study was to determine the levels of bone type I collagen synthesis and degradation biomarkers (PINP and β-CrossLabs) in children with acute hematogenous osteomyelitis.
References
2. Obukhova L. M., Erlykina E. I. Biochemistry. Metabolic Aspects of Pediatric Biochemistry: Textbook. – St. Petersburg: SpetsLit, 2023. – 464 p. ISBN 978-5-299-01082-4
3. Polivanova, T.V. Morpho-functional parameters of collagen in norm and pathology / T.V. Polivanova, V.T. Manchuk // Advances in Modern Natural Sciences. 2007. 一 Nº2 - C. 25-30; URL:
4. Асатова Ф. Ш. и др. ИММУНОХИМИЧЕСКИЕ МЕТОДЫ В КЛИНИЧЕСКОЙ БИОХИМИИ //INTERNATIONAL CONFERENCE ON ANALYSIS OF MATHEMATICS AND EXACT SCIENCES. – 2024. – Т. 1. – №. 1. – С. 39-43.
5. Toroptsova, N.V. Prediction of the Effectiveness of Therapy Using Biochemical Markers of Bone Metabolism / N.V. Toroptsova, O.A. Nikitinskaya // Ukrainian Rheumatological Journal. - 2011. - Vol. 3. - No. 45. - Pp. 35-38.
6. Butolin E. G. et al. ROLE OF BIOMARKERS OF ORGANIC MATRIX OF BONE TISSUE IN CHRONIC HEMATOGENOUS OSTEOMYELITIS IN CHILDREN //European journal of molecular medicine. – 2022. – Т. 2. – №. 5.
7. Krege, J.H. PINP as a biological response marker during teriparatide treatment for osteoporosis / J.H Krege, N.E. Lane, J.M. Harris [et al.] // Osteoporos Int. - 2014. - Vol.25. - Nº9. - P.2159-2171. DOI: http:/dx.doi.org/ 10.1007/s00198-014-2646-0.10:52
8. Vladislavovna K. O. The Prognostic Value of Markers of Bone Metabolism //International Journal of Medical Sciences And Clinical Research. – 2025. – Т. 5. – №. 05. – С. 88-91.
9. Raggatt, L.G. Cellular and Molecular Mechanisms of Bone Remodeling / L.G. Raggat, N.C. Partridge // J. Biol. Chem. - 2010. - Vol.285. - Nº33. - P.25103-25108.
